Publications

Journal Articles

    2025
  1. Okur MN, Ratajczak A, Kheradvar A, Djalilian H.
    Autologous mitochondrial transplantation enhances the bioenergetics of auditory cells and mitigates cell loss induced by H₂O₂.
    Mitochondrion, Volume 81, March 2025, 102003.
    Abstract    PDF
    2. 2024
  2. Sun A, Yeh L, Imanzadeh A, Kooraki S, Kheradvar A, Bedayat A.
    The Current Landscape of Artificial Intelligence in Imaging the Transcatheter Aortic Valve Replacement.
    Current Radiology Reports, 2024;12(11-12):113-120. doi: 10.1007/s40134-024-00431-w. Epub 2024 Oct 10.
    Abstract    PDF
  3. Hashemi MS, Farsiani Y, Pressman GS, Amini MR, Kheradvar A.
    Effect of Cross-Platform Variations on Transthoracic Echocardiography Measurements and Clinical Diagnosis.
    European Heart Journal – Imaging Methods and Practice, 2024 Sep 23;2(3):qyae097.doi: 10.1093/ehjimp/qyae097. eCollection 2024 Jul.
    Abstract    PDF
  4. Zareian R., Zuke S.D., Morisawa D., Geertsema R.S., Majid M., Wynne C., Milliken J.C., and Kheradvar A.
    Early Feasibility Study of a Hybrid Tissue-Engineered Mitral Valve in an Ovine Model.
    Journal of Cardiovascular Development and Disease, 2024 Feb 19;11(2):69. doi: 10.3390/jcdd11020069.
    Abstract    PDF
    5. 2023
  5. Agwu N, Recto M, Kheradvar A.
    Unmet Clinical Needs for Transcatheter Pulmonary Valves.
    Annals of Biomedical Engineering, 2023 Nov;51(11):2384-2392. doi: 10.1007/s10439-023-03328-5.
    Abstract    PDF
  6. Barrett A, Brown JA, Smith MA, Woodward A, Vavalle JP, Kheradvar A, Griffith BE, Fogelson AL.
    A Model of Fluid-Structure and Biochemical Interactions for Applications to Subclinical Leaflet Thrombosis.
    International Journal for Numerical Methods in Biomedical Engineering, 2023 Apr 4;e3700. doi: 10.1002/cnm.3700.
    Abstract    PDF
    7. 2022
  7. Kheradvar A and Pedrizzetti G.
    State of energy of ventricular flow: A cause or the first indicator of adverse remodeling?
    International Journal of Cardiology, 2022 Sep 23:S0167-5273(22)01392-4. doi: 10.1016/j.ijcard.2022.09.042.
    Abstract    PDF
  8. Trinidad F., Rubonal F., Rodriguez de Castro I., Pirzadeh I., Gerrah R., Kheradvar A. Rugonyi S.
    Effect of blood flow on cardiac morphogenesis and formation of congenital heart defects.
    Journal of Cardiovascular Development and Diseases, 2022 Sep 8;9(9):303. doi: 10.3390/jcdd9090303.
    Abstract    PDF
  9. Hosseinian S, Ali Pour P, Kheradvar A.
    Prospects of Mitochondrial Transplantation in Clinical Medicine: Aspirations and Challenges.
    Mitochondrion, 2022 Jul;65:33-44. doi: 10.1016/j.mito.2022.04.006. Epub 2022 Apr 30.
    Abstract    PDF
    10. 2021
  10. Gabbert DD, Kheradvar A, Jerosch-Herold M, Oechtering TH, Uebing AS, Kramer HH, Voges I, Rickers C.
    MRI-based Comprehensive Analysis of Vascular Anatomy and Hemodynamics.
    Cardiovascular Diagnosis and Therapy, 2021;11(6):1367-1378.
    Abstract    PDF
  11. Gabbert DD, Trotz P, Kheradvar A, Jerosch-Herold M, Scheewe J, Kramer HH, Voges I, Rickers C.
    Abnormal Torsion and Helical Flow Patterns of the Neo-Aorta in Hypoplastic Left Heart Syndrome Assessed with 4D-Flow MRI.
    Cardiovascular Diagnosis and Therapy, 2021;11(6):1379-1388.
    Abstract    PDF
  12. Rickers C, Wegner P, Silberbach M, Madriago E, Gabbert DD, Kheradvar A, Voges I, Scheewe J, Attmann T, Jerosch-Herold M, Kramer HH.
    Myocardial Perfusion in Hypoplastic Left Heart Syndrome.
    Circ Cardiovasc Imaging., 2021 Oct;14(10):e012468. doi: 10.1161/CIRCIMAGING.121.012468. Epub 2021.
    Abstract    PDF
  13. Goodwin RL, Kheradvar A, Norris RA, Price RL, Potts JD.
    Collagen Fibrillogenesis in the Mitral Valve: It's a Matter of Compliance.
    J Cardiovasc Dev Dis., 2021 Aug 20;8(8):98. doi: 10.3390/jcdd8080098.
    Abstract    PDF
  14. Ali Pour P, Hosseinian S, Kheradvar A
    Mitochondrial transplantation in cardiomyocytes: foundation, methods, and outcomes.
    Am J Physiol Cell Physiol., 2021 Sep 1;321(3):C489-C503. doi: 10.1152/ajpcell.00152.2021. Epub 2021 Jun 30.
    Abstract    PDF
  15. Kheradvar A, Vannan MA, Lakshmi DP, Pedrizzetti G.
    The effect of aortic root anatomy and vortex flow induced shear stress on the aortic valve leaflets.
    European Heart Journal - Cardiovascular Imaging, 24 March 2021. doi: 10.1093/ehjci/jeab031.
    Abstract    PDF
    16. 2020
  16. Karimi-Bidhendi A., Arafati A., Cheng A., Wu Y., Kheradvar A.*, Jafarkhani H.*
    Fully-Automated Deep-Learning Segmentation of Pediatric Cardiac MRI of Patients with Complex Congenital Heart Diseases.
    Journal of Cardiovascular Magnetic Resonance, 2020 Nov 30;22(1):80. doi: 10.1186/s12968-020-00678-0. (*co-corresponding author)
    Abstract    PDF
  17. Kheradvar A, Jafarkhani H, Guy TS, Finn JP.
    Prospect of artificial intelligence for the assessment of cardiac function and treatment of cardiovascular disease.
    Future Cardiology, 2020 Sep 16. doi: 10.2217/fca-2020-0128. Online ahead of print
    Abstract    PDF
  18. Arafati A, Morisawa D, Avendi MR, Amini, MR, Assadi RA, Jafarkhani H, Kheradvar A.
    Generalizable Fully Automated Multi-Label Segmentation of 4-Chamber View Echocardiograms based on Deep Convolutional Adversarial Networks.
    Journal of the Royal Society Interface, 2020, Aug;17(169):20200267.
    Abstract    PDF
  19. Wang DD, Qian Z, Vukicevic M, Engelhardt S, Kheradvar A, Zhang C, Little SH, Verjans J, Comaniciu D, O’Neill WW, Vannan MA.
    3D Printing, Computational Modeling and Artificial Intelligence for Structural Heart Disease.
    Journal of American College of Cardiology: Cardiovascular Imaging, 2020 Aug 25;S1936-878X(20)30515-5.
    Abstract    PDF
  20. Ali Pour P, Kenney CM, Kheradvar A.
    Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes.
    J Am Heart Assoc. 2020 Apr 7;9(7):e014501. doi: 10.1161/JAHA.119.014501. Epub 2020 Mar 23.
    Abstract    PDF
    21. 2019
  21. Arafati A, Hu P, Finn JP, Rickers C, Cheng AL, Jafarkhani H, Kheradvar A.
    Artificial Intelligence in Pediatric and Adult Congenital Cardiac MRI: An Unmet Clinical Need.
    Cardiovascular Diagnosis and Therapy, 2019 October Vol 9, Supplement 2.
    Abstract    PDF
  22. Kulkarni A, Morisawa D, Gonzalez D, Kheradvar A.
    Age-related Changes in Diastolic Function in Children: Echocardiographic Association with Vortex Formation Time.
    Echocardiography, 2019 October 36(10); 1869-1875.
    Abstract    PDF
  23. Kheradvar A, Rickers C, Morisawa D, Kim M, Hong GR, Pedrizzetti G.
    Diagnostic and Prognostic Significance of Cardiovascular Vortex Formation.
    Journal of Cardiology, 2019 Jun 26. pii: S0914-5087(19)30143-1
    Abstract    PDF
  24. Zareian R, Tseng JC, Fraser R, Meganck J, Kilduff M, Sarraf M, Dvir D, Kheradvar A.
    Effect of stent crimping on calcification of transcatheter aortic valves.
    Interactive CardioVascular and Thoracic Surgery, 2019 Jul 1;29(1):64-73
    Abstract    PDF    Journal Cover
  25. Gabbert D, Hart C, Jerosch-Herold M, Wegner P, Salehi Ravesh M, Voges I, Kristo I, AL Bulushi A, Scheewe J, Kheradvar A, Kramer HH, Rickers C
    Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation.
    Sci Rep, 2019 Feb 14;9(1):2034.
    Abstract    PDF

    26. 2018
  26. Morisawa D, Falahatpisheh A, Avenatti E, Little SH, Kheradvar A.
    Intraventricular Vortex Interaction between Transmitral Flow and Paravalvular Leak.
    Sci Rep., 2018 Oct 23;8(1):15657.
    Abstract     PDF

    27. 2017
  27. Kheradvar A, Zareian R, Kawauchi S, Goodwin RL, Rugonyi S.
    Animal Models for Heart Valve Research and Development.
    Drug Discov Today Dis Models, 2017 Summer;24:55-62
    Abstract     PDF
  28. Kheradvar A.
    On the accuracy of intracardiac flow velocimetry methods.
    J Echocardiography, 2017 Jun;15(2):67-69.
    Abstract     PDF
  29. Avendi MR, Kheradvar A, Jafarkhani H.
    Automatic Segmentation of the Right Ventricle from Cardiac MRI Using a Learning-based Approach.
    Magnetic Resonance in Medicine, 2017 Feb 16. doi: 10.1002/mrm.26631.
    Abstract     PDF
  30. Alavi SH, Soriano Baliarda M, Bonessio N, Valdevit L, Kheradvar A.
    A Tri-leaflet Nitinol Mesh Scaffold for Engineering Heart Valves.
    Annals of Biomedical Engineering, 2017 Feb;45(2):413-426.
    Abstract    PDF
  31. Dasi LP, Hatoum H, Kheradvar A, Zareian R, Alavi SH, Sun W, Martin C, Pham T, Wang Q, Midha PA, Raghav V, Yoganathan AP.
    On the Mechanics of Transcatheter Aortic Valve Replacement.
    Ann Biomed Eng. 2017 Feb;45(2):310-331.
    Abstract   PDF
  32. Falahatpisheh A and Kheradvar A.
    A framework for synthetic validation of 3D echocardiographic particle image velocimetry.
    Meccanica, 2017 Feb, 52(3): 555–561.
    Abstract   PDF

  33. Falahatpisheh A, Morisawa D, Toosky TT, Kheradvar A.
    A Calcific Polymeric Valve for Valve-in-Valve Applications.
    Journal of Biomechanics, 2017 Jan; 50(1): 77.82.
    Abstract   PDF
  34. Hajiaghayi M, Groves EM, Jafarkhani H, Kheradvar A.
    A 3D Active Contour Method for Automated Segmentation of the Left Ventricle from Magnetic Resonance Images.
    IEEE Trans Biomed Eng. 2017 Jan;64(1):134-144.
    Abstract   PDF

    35. 2016
  35. Sievers HH, Kheradvar A, Kramer HH and Rickers C.
    3D Heart Model and 4D Flow MRI 20 Years after Spiral Arterial Switch Operation.
    Thorac Cardiov Surg Reports, 2016 Dec; 05(01): 44-46.
    Abstract   PDF
  36. Sievers HH, Putman LM, Kheradvar A, Gabbert D, Wegner P, Scheewe J, Salehi-Ravesh M, Kramer HH, Rickers C.
    4D flow streamline characteristics of the great arteries twenty years after Lecompte and direct spiral arterial switch operation (DSASO) in simple TGA.
    Global Cardiology Science and Practice, 2016 (3):29.
    Abstract     PDF    Journal Cover
  37. Avendi MR, Kheradvar A, Jafarkhani H.
    A Combined Deep-Learning and Deformable-Model Approach to Fully Automatic Segmentation of the Left Ventricle in Cardiac MRI.
    Medical Image Anal. 2016 Jun;22(6):817-25.
    Abstract   PDF
  38. Falahatpisheh A, Rickers C, Gabbert D, Heng EL, Stalder A, Kramer HH, Kilner PJ, Kheradvar A.
    Simplified Bernoulli's method significantly underestimates pulmonary transvalvular pressure drop.
    J Magn Reson Imaging. 2016;43:1313.1319
    Abstract   PDF     Journal Cover
  39. Rickers C, Kheradvar A, Sievers HH, Falahatpisheh A, Wegner P, Gabbert D, Jerosch-Herold M, Hart C, Voges I, Putman LM, Kristo I, Fischer G, Scheewe J, Kramer HH.
    Is the Lecompte technique the last word on transposition of the great arteries repair for all patients? A magnetic resonance imaging study including a spiral technique two decades postoperatively.
    Interact Cardiovasc Thorac Surg 2016 Feb 6;30:108-119.
    Abstract   PDF

    40. 2015
  40. Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Hamed Alavi S, Tranquillo R, Dasi LP, Simmons CA, Jane Grande-Allen K, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B.
    Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies.
    Ann Biomed Eng. 2015 Oct;43(10):2314-33
    Abstract   PDF
  41. Pedrizzetti G, Vlachos PP, Little WC, Sotiropoulos F, Gharib M, Kheradvar A.
    Comments on Defining the Contribution of Diastolic Vortex Ring to Left Ventricular Filling.
    Journal of American College of Cardiology. 2015 Jun 16;65(23):2573-4
    Abstract   PDF
  42. Alavi SH, Sinha A, Steward E, Milliken JC, Kheradvar A.
    Load Dependent Extracellular Matrix Organization in Atrioventricular Heart Valves: Differences and Similarities.
    Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H276-84. doi: 10.1152/ajpheart.00164.2015.
    Abstract   PDF
  43. Alavi SH and Kheradvar A.
    A Hybrid Tissue-Engineered Heart Valve.
    The Annals of Thoracic Surgery. 2015 Jun;99(6):2183-7.
    Abstract   PDF
  44. Falahatpisheh A, Pahlevan NM, Kheradvar A.
    Effect of the Mitral Valve's Anterior Leaflet on Axisymmetry of Transmitral Vortex Ring.
    Annals of Biomedical Engineering. 2015 Oct;43(10):2349-60
    Abstract   PDF
  45. Kheradvar A, Groves EM and Tseng E.
    FOLDAVALVE: A Novel 14Fr Totally Repositionable and Retrievable Transcatheter Aortic Valve: Proof of Concept in Sheep.
    EuroIntervention. 2015 Sep;11(5):591-6. doi: 10.4244/EIJY15M03_04.
    Abstract   PDF
  46. Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo RT, Grande-Allen KJ, Simmons CA, Griffith BE, Falahatpisheh A, Goergen CJ, Mofrad MRK, Baaijens FPT, Little SH, Canic S.
    Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future.
    Annals of Biomedical Engineering, 2015 Apr;43(4):833-43.
    Abstract   PDF
  47. Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo RT, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MRK, Falahatpisheh A, Griffith BE, Baaijens FPT, Little SH, Canic S.
    Emerging Trends in Heart Valve Engineering: Part II. Novel and Standard Technologies for Aortic Valve Replacement.
    Annals of Biomedical Engineering, 2015 Apr;43(4):844-57.
    Abstract   PDF
  48. Falahatpisheh A, Pedrizzetti G, Kheradvar A.
    Three-Dimensional Reconstruction of Cardiac Flows Based on Multi-Planar Velocity Fields.
    Experiments in Fluids, 2014 Nov, 55 (11) Article Number: 1848.
    Abstract   PDF
  49. Falahatpisheh A, Kheradvar A.
    A Measure of Axisymmetry for Vortex Rings.
    European Journal of Mechanics - B/Fluids, Volume 49, Part A, January.February 2015, Pages 264.271.
    Abstract   PDF
  50. Kheradvar A, Groves EM, Simmons CA, Griffith BE, Alavi SH, Tranquillo RT, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MRK, Baaijens FPT, Canic S, Little SH.
    Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for mitral valve repair and replacement.
    Annals of Biomedical Engineering, 2015 Apr;43(4):858-70.
    Abstract   PDF

    51. 2014
  51. Groves EM, Falahatpisheh A, Su JL, Kheradvar A.
    The Effects of Positioning of Transcatheter Aortic Valve on Fluid Dynamics of the Aortic Root.
    ASAIO Journal, 2014 Sep-Oct;60(5):545-52.
    Abstract    PDF    Journal Cover
  52. Alavi SH, Groves EM, Kheradvar A.
    The Effects of Transcatheter Valve Crimping on Pericardial Leaflets.
    The Annals of Thoracic Surgery, 2014 Apr;97(4):1260-6.
    Abstract     PDF

    53. 2013
  53. Mangual JO, Föll D, Jung B, Pedrizzetti G, Kheradvar A.
    Aging does not Affect Radial Viscoelastic Behavior of the Left Ventricle.
    Cardiology, 2013;125(1):38-49.
    Abstract     PDF
  54. Abe H, Caracciolo G, Kheradvar A, Pedrizzetti G, Khandheria BK, Narula J, Sengupta PP.
    Contrast echocardiography for assessing left ventricular vortex strength: a prospective case.control pilot study in heart failure.
    European Heart Journal - Cardiovascular Imaging, 2013 Nov;14(11):1049-60.
    Abstract    PDF
  55. Alavi SH, Ruiz V, Krasieva T, Botvinick EL, and Kheradvar A.
    Characterizing the Collagen Fiber Orientation in Pericardial Leaflets under Mechanical Loading Conditions.
    Annals of Biomedical Engineering, 2013, 41 (3) 547-561.
    Abstract    PDF
  56. Alavi SH, Liu WF, Kheradvar A.
    Inflammatory Response Assessment of a Hybrid Tissue-Engineered Heart Valve Leaflet.
    Annals of Biomedical Engineering, 2013, 41 (2) 316-26.
    Abstract    PDF

    57. 2012
  57. Falahatpisheh A, Kheradvar A.
    High-Speed Particle Image Velocimetry to Assess Cardiac Fluid Dynamics in vitro: From Performance to Validation.
    European Journal of Mechanics - B/Fluids, 35 (2012) 2-8.
    Abstract    PDF
  58. Sengupta PP, Pedrizzetti G, Kilner PJ, Kheradvar A, Ebbers T, Tonti G, Fraser, AG, Narula, J.
    Emerging Trends in Cardiovascular Flow Visualization
    Journal of American College of Cardiology: Cardiovascular Imaging, 2012, 5; 305-16.
    Abstract    PDF    Journal Cover
  59. Kheradvar A, Falahatpisheh, A.
    The Effects of Dynamic Saddle Annulus and Leaflet Length on Transmitral Flow Pattern and Leaflet Stress of a Bi-leaflet Bioprosthetic Mitral Valve.
    Journal of Heart Valve Disease, 2012, 21; 225-233.
    Abstract    PDF
  60. Alavi SH, Kheradvar A.
    Metal Mesh Scaffold for Tissue Engineering of Membranes.
    Tissue Engineering Part C: Methods,2012, 18 (4), 2012, 18 (4); 293-301.
    Abstract    PDF    Journal Cover    Journal Cover 2
  61. Kheradvar A, Assadi R, Falahatpisheh A,Sengupta PP.
    Assessment of Transmitral Vortex Formation in Patients with Diastolic Dysfunction.
    Journal of American Society of Echocardiography, 2012, 25 (2) 220-7.
    Abstract   PDF    Journal Cover

    62. 2010
  62. Mangual JO, Jung B, Ritter JA, Kheradvar A
    Modeling Radial Viscoelastic Behavior of Left Ventricle based on MRI Tissue Phase Mapping.
    Annals of Biomedical Engineering, 2010, 38 (10) 3102-3111.
    Abstract   PDF
  63. Kheradvar A, Houle H, Pedrizzetti G, Tonti G, Belcik T, Ashraf M, Lindner JR, Gharib M, Sahn DJ
    Echocardiographic Particle Image Velocimetry: A Novel Technique for Quantification of Left Ventricular Blood Vorticity Pattern.
    Journal of American Society of Echocardiography (JASE 2010, 23(1) 86-94.
    Abstract   PDF

    64. 2009
  64. Grosberg A, Gharib M, Kheradvar A
    The Effect of Fiber Geometry on Pulsatile Pumping and Energy Expenditure.
    Bulletin of Mathematical Biology, 2009, 71: 1580–1598.
    Abstract   PDF
  65. Kheradvar A, Gharib M
    On Mitral Valve Dynamics and its connection to Early Diastolic Flow.
    Annals of Biomedical Engineering, 2009 Jan, 37(1):1-13.
    Abstract   PDF

    66. 2007
  66. Kheradvar A, Gharib M
    Influence of ventricular pressure-drop on mitral annulus dynamics through the process of vortex ring formation.
    Annals of Biomedical Engineering 2007, 35 (12):2050-2064.
    Abstract   PDF
  67. Kheradvar A, Milano M, Gharib M
    Correlation between vortex ring formation and mitral annulus dynamics during ventricular rapid filling.
    ASAIO Journal (Journal of American Society of Artificial Internal Organs), Jan-Feb 2007 53(1): 8-16.
    Abstract    PDF

    68. 2006
  68. Kheradvar A, Milano M, Gorman RC, Gorman III JH, Gharib M
    Assessment of left ventricular viscoelastic components based on ventricular harmonic behavior.
    Cardiovascular Engineering, 2006 March 6(1): 30-39.
    Abstract   PDF
  69. Gharib M, Rambod E, Kheradvar A, Sahn DJ, Dabiri JO
    A global index for heart failure based on optimal vortex formation in the left ventricle.
    Proceedings of National Academy of Sciences (PNAS) 2006, 103 (16): 6305-6308.
    Abstract   PDF
  70. Kheradvar A, Kasalko J, Johnson D, Gharib M
    An in-vitro study of changing profile heights in mitral bioprostheses and their influence on flow.
    ASAIO Journal 2006 Jan-Feb 52(1):34-38.
    Abstract   PDF

    71. 2005
  71. Amirzargar AA, Tabassi A, Khosravi F, Kheradvar A, Rezaei N, Naroueynejad M, Ansaripour B, Moradi B, Nikbin B
    Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study.
    European Journal of Neurology 2005 Jan;12(1):25-30.
    Abstract   PDF

    72. 2004
  72. Kheradvar A, Tabassi AR, Nikbin B, Khosravi F, Naroueynejad M, Moradi B, Amirzargar AA
    Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study.
    Multiple Sclerosis. 2004 Oct;10(5):526-31.
    Abstract   PDF

    73. 2002
  73. Rad AS, Jabbarvand M, Farahvash MM, Kheradvar A
    Laser in situ keratomileusis and diode thermal keratoplasty for correction of hyperopia from +5.00 to +10.00 diopters.
    Journal of Refractive Surgery. 2002 May-Jun;18(3 Suppl):S318-20.
    Abstract    PDF

    74. 2001
  74. Rad AS, Kheradvar A
    Juvenile xanthogranuloma: concurrent involvement of skin and eye cornea.
    The Journal of Cornea and External disease. 2001 Oct;20(7):760-2.
    Abstract   PDF

    75. 2000
  75. Behnia H, Kheradvar A, Shahrokhi M
    An anatomic study of the lingual nerve in the third molar region.
    Journal of Oral & Maxillofacial Surgery. 2000 Jun;58(6):649-51.
    Abstract   PDF